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On the Frontline: How Primary Care Physicians Are Tackling Depression

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Aug. 1 2025

When most people think of treating depression, they picture therapists or psychiatrists. But increasingly, it's primary care physicians (PCPs) who are playing a leading role in identifying and managing this common and often misunderstood condition. With one in five adults in the U.S. experiencing depression at some point in their lives, the exam room of a family doctor or internist has become a crucial access point for mental health care.

The First Line of Defense
Primary care physicians are often the first professionals patients turn to when they're struggling with unexplained fatigue, sleep issues, chronic pain, or just not feeling like themselves. These symptoms are frequently rooted in depression, even when patients don't recognize it or are hesitant to talk about it. Because of their ongoing relationships with patients and families, PCPs are in a unique position to notice changes in behavior or mood that may signal a deeper issue.

Dr. Sarah Lim with Internal Medicine Associates says, "Mental health issues are so common in primary care. About half the patients I see are already diagnosed with depression or anxiety, or are there to talk about symptoms they're experiencing that indicate depression or anxiety. A common symptom is apathy or lack of motivation to do things they used to enjoy."

Treating the Whole Person
Unlike specialists who focus on one area of health, primary care doctors view patients through a holistic lens. They understand how physical health, lifestyle, and emotional well-being are all interconnected. That perspective is especially important when treating depression, which is frequently linked to—or worsened by—chronic medical conditions like diabetes, heart disease, or obesity.

PCPs can initiate treatment by prescribing antidepressants, recommending therapy, or referring patients to mental health professionals when needed. "The first line medications we use for depression are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), which work on different receptors in the brain. Most patients feel some improvement within a week or two of starting medication, but it takes four to six weeks to achieve the full benefit," says Dr. Lim

"It's important to treat depression and anxiety from all angles,” says Dr. Lim. “While medication is beneficial, it's also important to talk with a support person, whether that's a therapist, clergy member or friend. I also suggest patients exercise and spend time outdoors in the sunshine to help lift their mood."

"Usually we can manage depression and anxiety in the primary care office. But, if someone has tried several first-line medications and is not getting better or if there are other mental health issues complicating the picture, then we may refer to a psychiatrist to manage their medication," Dr. Lim notes.

Fighting Stigma and Increasing Access
One of the biggest barriers to mental health care is stigma. Some patients may feel embarrassed or ashamed to seek help from a mental health specialist, but they're more comfortable talking to the doctor they've known for years. By normalizing conversations about mental health in everyday checkups, PCPs are helping to break down that stigma and make care more accessible.

The Takeaway
Depression is one of the most treatable mental health conditions—but only if it's recognized and addressed early. Primary care physicians are not just generalists; they are trusted partners, listeners, and advocates who often guide patients through their first steps toward healing. As frontline providers, they play a vital role in improving access, reducing stigma, and ensuring patients receive the comprehensive care they need, both body and mind.

If you're feeling persistently down, tired, or overwhelmed, talk to your primary care doctor. Mental health is health, and help can start with a simple conversation.

Head shot of Dr. Sarah Lim
Sarah L. Lim, DOInternal Medicine Associates

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Disclaimer: This blog is intended for general understanding and education about Lexington Medical Center. Nothing on the blog should be considered or used as a substitute for medical advice, diagnosis or treatment. Blog visitors with personal health or medical questions should consult their health care provider.